Hard science and a TV sitcom seems like a strange recipe for a successful TV show, but The Big Bang Theory makes it work. This show speaks to every persons geek side through references from science fiction and comics to high level physics and advanced math. The thing that sells the show is the science. Here is a great interview with David Saltzberg, science advisory to show, Link to Intierview. He also keeps up a blog about the research he does for each episode here is the link to his show blog Link to David's Blog. Link to the science behind each episode of The Big Bang Theory.
http://thebigblogtheory.wordpress.com/